Table 1.
Principal features of studies that searched for an association between gene expression and suicide.
| First Author | Year of Publication | Location | Brodmann Area | GE Lab Method | Some Genes Analyzed | NOS |
|---|---|---|---|---|---|---|
| USA | ||||||
| Hiroi N [11] | 2001 | AMY, THAL, PG, HPC, CB, SN | NA | qRT–PCR | CRH-R1, CRH-R2 | 7 |
| Dwivedi Y [12] | 2001 | PFC, HPC, CB | 8, 9, 10 | qRT–PCR | MKP2, ERK1/2 | 8 |
| Dwivedi Y [13] | 2003 | PFC, HPC | 9 | qRT–PCR | BNDF, TrkB | 9 |
| Sibille E [14] | 2004 | PFC | 9, 47 | Microarray | BDNF, TrkB, CREB, HTR1A, HTR2C, ADRA1A, ADRA2B | 9 |
| Choudary PV [16] | 2005 | ACC, DLPFC | 24, 9, 46 | Microarray | GABAAα1, GABAAß3 | 8 |
| Kim S [21] | 2007 | PFC | 46/10 | Microarray | PLSCR4, EMX2 | 6 |
| Garbett K [25] | 2008 | PFC | NA | Microarray | TOB1, NFIA, TLOC, AL119182, HTR2A | 9 |
| Pandey GN [28] | 2009 | PFC, HPC | 9 | qRT–PCR | GSK-3b | 8 |
| Simmons M [33] | 2010 | DLPFC | NA | qRT–PCR | ADAR1 | 7 |
| Choi K [36] | 2011 | PFC, HPC | 46 | Microarray | CAMK2B, CDK5, MAPK9, PRKCI | 7 |
| Sequeira A [40] | 2012 | DLPFC, ACC, NACC | NA | Microarray | 5-HT2A, MT1E, MT1F, MT1G, MT1H, MT1X, MT2A | 8 |
| Galfalvy H [42] | 2013 | DLPFC, ACC | 9, 24 | Microarray | CYP19A1, MBNL2, KTBBD2, FOXN3, DSC2, CD300LB | 8 |
| Ren X [43] | 2013 | PFC, HPC | 9 | qRT–PCR | GSK-3b, b-catenin | 8 |
| Pandey GN [45] | 2013 | PFC, HPC, AMY | 9 | qRT–PCR | GR-α, GR | 7 |
| Gray AL [51] | 2015 | DLPFC | NA | qRT–PCR | GRIN2B, GRIK3, GRM2 | 9 |
| Fuchsova B [52] | 2015 | PFC | 9 | qRT–PCR | GPM6A, GPM6B | 9 |
| Gray AL [51] | 2015 | DLPFC | NA | qRT–PCR | GRIN2B, GRIK3, GRM2 | 9 |
| Fuchsova B [52] | 2015 | PFC | 9 | qRT–PCR | GPM6A, GPM6B | 9 |
| Zhao J [53] | 2015 | DLPFC, ACC | 24, 9 | qRT–PCR | CRH, NIDD | 9 |
| Yin H [54] | 2016 | DLPFC | 9 | Microarray | NR3C1 | 9 |
| Pandey GN [55] | 2016 | PFC | 9 | qRT–PCR | SKA2 | 8 |
| Pantazatos SP [57] | 2017 | DLPFC | 9 | NGS | MTRNR2L8, SERPINH1 | 7 |
| Zhang L [61] | 2020 | DLPFC, ACC | 46, 24 | qRT–PCR | P2RY12 | 8 |
| Zhang Lb [62] | 2020 | DLPFC, ACC | 46, 24 | qRT–PCR | TREM2, P2RY12 | 8 |
| Yoshino Y [5] | 2020 | DLPFC | 9 | Microarray | GRP78, GRP94, ATF4C | 8 |
| Pandey GN [7] | 2021 | PFC | 9 | qRT–PCR | CXCL1, CXCL2, CXCL3, CCL2 | 8 |
| Canada | ||||||
| De Luca V [18] | 2006 | DLPFC | 46 | qRT–PCR | TPH2 | 8 |
| Sequeira A [19] | 2006 | OC, DLPFC, MC | 4, 8/9, 11 | Microarray | SSAT | 7 |
| Sequeira A [20] | 2007 | AMY, HPC, ACG, PCG | 24, 29 | Microarray | ADCY8, APLP2 | 7 |
| Feldcamp LA [24] | 2008 | DLPFC | 46 | qRT–PCR | DARPP-32 | 9 |
| McGowan PO [26] | 2009 | HPC | NA | qRT–PCR | NR3C1 | 7 |
| Ernst C [27] | 2009 | FC, CB | 4, 6, 10, 11, 44, 45, 46, 47, 8/9 | Microarray | TrkB.T1 | 6 |
| Klempan TA [29] | 2009 | OFC, IFG | 4, 6, 8/9, 10, 11, 20, 21, 24, 29, 38, 44, 45, 46, 47 | Microarray | QKI | 9 |
| Sequeira A [30] | 2009 | ACC | NA | Microarray | GABARAPL1, GABARA4, GABARB1, GRIA3, GRIA4, GRIA1 | 9 |
| Lalovic A [31] | 2010 | DLPFC, OFC, VPFC | 8/9, 11, 47 | Microarray | FADS1, LEPR, PIK3C2A, SCD | 8 |
| Fiori LM [37] | 2011 | AMY, CB, HPC, HPT, NACC, THAL | 4, 6, 8/9, 10, 11, 20, 21, 24, 29, 38, 44, 45, 46, 47 | Microarray | SAT1, ALDH3A2, AMD1, ARG2 | 7 |
| Smalheiser N [39] | 2012 | PFC | 9 | RT-PCR | DMNT3b, BCL2 | 9 |
| Labonté B [41] | 2013 | HPC, DG | NA | Microarray | NR2E1, GRM7 | 8 |
| Gross J [46] | 2013 | 44 | Microarray | OAZ1, OAZ2, AMD1, ARG2 | 7 | |
| Lopez JP [47] | 2014 | PFC | 44 | qRT–PCR | SAT1, SMOX | 7 |
| Nagy C [56] | 2017 | MDTHAL, CN, CBTX, CTX | 4, 17 | qRT–PCR | CX30, CX43 | 8 |
| Postolache TT [64] | 2020 | DLPFC, ACC | 46, 24, 32, 33 | qRT–PCR | CRAMP | 9 |
| Squassina A [65] | 2020 | ACG | 24 | qRT–PCR | PRKAB2, CREB1, PTEN, PRKAG1, PTPN11, INSR | 9 |
| Mexico | ||||||
| Cabrera B [60] | 2019 | PFC | 9 | Microarray | ARL16, KLHL28, SUCLA2, ATP6V0C, TRAK2, CDK19, FNBP1 | 8 |
| Cabrera-Mendoza Bb [63] | 2020 | DLPFC | 9 | Microarray | BBS4, NKX6-2, AXL, CTNND1, MBP, PAOX | 8 |
| Romero-Pimentel A [66] | 2021 | DLPFC | 9 | Microarray | ADCY9, CRH, NFATC4, ABCC8, HMGA1, KAT2A, EPHA2, TRRAP | 9 |
| Asian countries | ||||||
| Yanagi M [17] | 2005 | AMY | NA | Microarray | 14-3-3 ε | 8 |
| Tochigi M [22] | 2008 | PFC | 10 | Microarray | CAD, ATP1A3 | 9 |
| Sherrin T [15] | 2004 | CB, CG, PFC | NA | qRT–PCR | CCKB | 8 |
| European countries | ||||||
| Thalmeier A [23] | 2008 | OFC | 11 | Microarray | AMPH, CDH12, CDH22, CHGB, MYR8, PENK, PTPRR, SCN2B | 9 |
| Perroud N [32] | 2010 | VPFC | 11 | qRT–PCR | TPH2 | 7 |
| Keller S [34] | 2010 | Wernicke | NA | Microarray | BDNF | 7 |
| Keller S [35] | 2011 | Wernicke | 8, 9 | Microarray | TrkB | 7 |
| Zhurov V [38] | 2012 | FPC | 10 | Microarray | MEF2D, TFE3, PLAGL1, C1D, XRCC5, EP300, FMR1, VTA1 | 8 |
| Pérez-Ortiz JM [44] | 2013 | AMY | NA | qRT–PCR | FKBP5, GR | 7 |
| Du L [49] | 2014 | FPC, OFC | 10, 11, 12, 45, 47 | qRT–PCR | COMT | 8 |
| Monsalve E [50] | 2014 | DLPFC, AMY | NA | qRT–PCR | NOTCH2, NOTCH1, NOTCH3, NOTCH4, DLL4, JAGGED1 | 9 |
| García-Gutiérrez MS [58] | 2018 | DLPFC | 9 | qRT–PCR | CB2r, GPR55 | 8 |
| Kouter K [59] | 2019 | PFC, HPC | 9 | NGS | NRIP3, ZNF714 | 8 |
| Mixed populations | ||||||
| Di Narzo AF [48] | 2014 | OFC, ACC | 11, 25 | Microarray | 5 HT2CR | 7 |
| Cabrera-Mendoza B [8] | 2020 | DLPFC | 9 | Microarray | GRM3, GRM8, GRIA2, GRIN2A, GRIN2C | 8 |
PFC: prefrontal cortex; DLPFC: dorsolateral prefrontal cortex; ACC: anterior cingulate cortex; ACG: anterior cingulate gyrus; HPC: hippocampus; HPT: hypothalamus; AMY: amygdala; THAL: thalamus; PG: pituitary; CB: cerebellum; SN: substantia nigra; CG: cingulate gyrus; PCG: posterior cingulate gyrus; OC: orbital cortex; MC: motor cortex; OFC: orbitofrontal cortex; FC: frontal cortex; IFG: inferior frontal gyrus; VPFC: ventral prefrontal cortex; NACC: nucleus accumbens; DG: dentate gyrus; MDTHAL: mediodorsal thalamus; CN: caudate nucleus; CBTX: cerebellar cortex; CTX: cerebral cortex; qRT–PCR: real-time quantitative reverse transcription PCR; NGS: next-generation sequencing; NA: not available. USA: United States of America; NOS: Newcastle-Ottawa Scale.