Chart 1.

Representative scope of FDH-catalyzed haloetherification of 1,1-disubstituted alkenes^a,b

^aReactions conducted at room temperature for times specified in the supporting information using 1 mM substrate, 5 mM NaBr, 5 mol% FDH, 100 μM NAD and FAD, 20 mM glucose, 1 mM glutathione, 2.5 μM RebF, 9 U/mL GDH, and 35 U/mL catalase in 200 mM tricine, pH 7.5. ^bYields determined by LC/MS relative to internal standard; selectivities determined by chiral HPLC. ^cVariant 4PL-F111S was used in place of 4PL. ^dA 64:36 mixture of E/Z-8 was used.^e Variant 2RFQ-F111S was used in place of 4PL. ^f5 mM NaCl used in place of NaBr.