Table 2.
Association of a 1-Hour Treatment Delay with Functional Independence (mRS 0–2) at 90 Days in Patients Treated With Endovascular Therapy
| Unadjusted OR per 1-hour delay (95% CI) | Unadjusted ARD, % (95% CI) | Model 1 | Model 2 | |||
|---|---|---|---|---|---|---|
| aOR per 1-hour delay (95% CI)* | aARD, % (95% CI)* | aOR per 1-hour delay (95% CI)* | aARD, % (95% CI)* | |||
| All (n=257) | ||||||
| OTA | 0.89 (0.82 to 0.96) | −2.8 (−4.4 to −1.2) | 0.89 (0.81 to 0.98) | −1.8 (−3.2 to −0.3) | 0.89 (0.81 to 0.99) | −1.6 (−3.1 to −0.2) |
| OTP | 0.89 (0.82 to 0.96) | −2.7 (−4.5 to −1.0) | 0.88 (0.79 to 0.98) | −2.0 (−3.5 to −0.4) | 0.88 (0.79 to 0.98) | −1.8 (−3.4 to −0.3) |
| OTR | 0.89 (0.82 to 0.96) | −2.8 (−4.5 to −1.0) | 0.88 (0.79 to 0.98) | −1.9 (−3.5 to −0.4) | 0.89 (0.79 to 0.99) | −1.8 (−3.3 to −0.2) |
| IV-tPA given (n=149)† | ||||||
| OTA | 0.74 (0.61 to 0.88) | −5.8 (−8.9 to −2.8) | 0.81 (0.63 to 1.04) | −2.4 (−5.1 to 0.3) | 0.81 (0.64 to 1.04) | −2.3 (−4.8 to 0.3) |
| OTP | 0.79 (0.68 to 0.94) | −4.6 (−7.5 to −1.6) | 0.86 (0.68 to 1.08) | −1.8 (−4.3 to 0.8) | 0.87 (0.69 to 1.09) | −1.6 (−4.2 to 0.9) |
| OTR | 0.80 (0.69 to 0.94) | −4.4 (−7.1 to −1.6) | 0.88 (0.70 to 1.09) | −1.5 (−4.0 to 0.9) | 0.89 (0.72 to 1.11) | −1.3 (−3.7 to 1.1) |
| FI by CT (n=174)‡ | ||||||
| OTA | 0.81 (0.73 to 0.90) | −4.7 (−6.5 to −2.8) | 0.83 (0.72 to 0.94) | −2.7 (−4.4 to −1.0) | 0.84 (0.74 to 0.96) | −2.4 (−4.2 to −0.7) |
| OTP | 0.80 (0.72 to 0.90) | −4.7 (−6.7 to −2.8) | 0.80 (0.69 to 0.92) | −3.2 (−5.1 to −1.4) | 0.81 (0.70 to 0.94) | −3.0 (−4.9 to −1.0) |
| OTR | 0.80 (0.71 to 0.89) | −4.9 (−6.9 to −3.0) | 0.79 (0.68 to 0.92) | −3.3 (− 5.2 to −1.4) | 0.81 (0.69 to 0.94) | −3.0 (−5.0 to −1.1) |
ARD indicates absolute risk difference; aARD, adjusted absolute risk difference; aOR, adjusted odds ratio; CT, computed tomography; FI, final infarct; IV-tPA, intravenous tissue-type plasminogen activator; mRS, modified Rankin Scale; OR, odds ratio; OTA indicates onset to admission; OTP, onset to puncture; and OTR, onset to reperfusion.
Adjusted ORs and absolute risk differences in predicted probabilities by hour were estimated from logistic regressions. The study adjusted for age, sex, stroke severity as baseline National Institutes of Health Stroke scale, prestroke mRS, location of occlusion, and additionally for final infarct as FIASPECTS at 24—48 hours in Model 1 and for FIVOLUME final infarct volume in Model 2.
Analysis was restricted to patients who received IV-tPA before the endovascular treatment.
Analysis was restricted to patients whose FI was determined using computed tomography.