Table 1.
In vitro experimental cell culture models of NAFLD/NASH/NASF for GLP1-RA treatment research.
| Cell Line | Compounds Used to Induce Cell Culture Model of Hepatic Steatosis * |
GLP1-RA Compound | Reference |
|---|---|---|---|
| Primary hepatocytes Hep-G2 HuH7 |
Palmitic acid Oleic acid |
GLP-1 Exendin-4 |
[21] |
| Huh7 | Oleic acid Amiodarone |
Liraglutide | [26] |
| HepG2 | Oleic acid | Exendin-4 | [49] |
| HepG2 | Oleic acid | AWRK6 (synthetic peptide) | [56] |
| HepG2 | Palmitic acid | Liraglutide | [57,79] |
| L02 | Palmitic acid | Exenatide | [62] |
| HepG2 | High glucose | Liraglutide | [66] |
| Hepg2 | Palmitic acid | Liraglutide | [69] |
| HepG2 | Palmitic acid Oleic acid |
Liraglutide | [70] |
| HepG2 | Oleic acid LPS |
Exenatide | [75] |
| Primary mice Kupffer cells (KCs) | Palmitic acid | Liraglutide | [76,77] |
| AML12 + JS-1 | Palmitic acid (AML12) H2O2 (AML12) |
Liraglutide | [78] |
* insulin resistance/high glucose environment/NASH.