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Differentiation of iPSCs into astrocytes: (A) Diagrammatic representation of differentiation of astrocytes from iPSCs. The iPSCs were differentiated into neural progenitor (NP) cells from which glial progenitor cells (GPC) were generated. The GPCs were then differentiated into astrocytes. (B,C) Representative phase contrast images for the healthy control (B) iPSC line and the patient-derived iPSC line carrying the PD LRRK2-I1371V mutation (C) at different stages of differentiation.
