Table 3.
Univariate and multivariate Cox analysis of 5–year disease–free survival in locally advanced rectal cancer after surgery.
| Factor | Number (n) | Univariate Cox Analysis | Multivariate Cox Analysis | |||
|---|---|---|---|---|---|---|
| HR (95%CI) | p | C–Index | HR (95%CI) | p | ||
| Tumor length | 0.016 | 0.585 | 0.53 | |||
| ≤4 cm | 86 | 1 | ||||
| >4 cm | 123 | 2.328 (1.144–4.736) | 1.304 (0.57–2.985) | |||
| MRF | 0.018 | 0.591 | 0.356 | |||
| Negative | 137 | 1 | ||||
| Positive | 72 | 2.05 (1.119–3.755) | 0.704 (0.335–1.482) | |||
| EMVI | <0.001 | 0.678 | 0.009 | |||
| Negative | 120 | 1 | ||||
| Positive | 89 | 4.102 (2.098–8.018) | 2.799 (1.292–6.062) | |||
| LPLN | <0.001 | 0.636 | 0.015 | |||
| Negative | 151 | 1 | ||||
| Positive | 58 | 3.42 (1.863–6.281) | 2.251 (1.17–4.332) | |||
| cT | 0.036 | 0.555 | 0.654 | |||
| T3 | 186 | 1 | ||||
| T4 | 23 | 2.245 (1.036–4.862) | 1.211 (0.524–2.801) | |||
| CA19–9 | 0.014 | 0.234 | ||||
| Negative | 185 | 1 | ||||
| Positive | 24 | 2.461 (1.177–5.146) | 1.629 (0.73–3.638) | |||
| radscore | 0.034 | 0.576 | 0.78 | |||
| ≥0.688 | 52 | 1 | ||||
| <0.688 | 157 | 2.303 (1.065–4.977) | 1.126 (0.489–2.595) | |||
| pCR | 0.007 | 0.59 | 0.103 | |||
| No | 165 | 1 | ||||
| Yes | 44 | 0.176 (0.043–0.728) | 0.294 (0.068–1.279) | |||
p–values < 0.05 are shown in bold. Abbreviations: HR, hazard ratio; MRF, mesorectal fascia involvement, EMVI, extramural vascular invasion; LPLN, lateral pelvic lymph node; CA199, carbohydrate antigen 199; pCR, complete pathological response.