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Schematic representation of glial cell populations involved in pain transmission. After painful stimuli, Schwann cells and SGCs in the PNS become activated and release pro-inflammatory mediators that sensitize nociceptors. In the CNS, astrocytes, and microglia respond to noxious stimulation changing their morphology into an activated phenotype and releasing bioactive factors. See text for details. Created with BioRender.com, accessed on 28 April 2023.
