Figure 7.

Association between cIAP1 levels and response to IR and Xevinapant therapy: (A) cIAP1 background levels in relation to apoptotic cells in seven HNSCC cell lines and one healthy cell line measured by AnnexinV flow cytometry. Line represents linear regression. (B) cIAP1 background levels associated with number of γH2AX foci per cell after 2 Gy IR. (C) cIAP1 background levels associated with apoptotic cells in flow cytometry and survival fraction (SF) in colony formation assay after IR. (D) cIAP1 background levels associated with apoptotic cells and SF after treatment with Xevinapant alone or combined with IR. The line represents linear regression. An open circle means that the cell line was excluded from the regression.