Figure 13.
Structural overview of dexamethasone (gray) bound in the GR LBP with hydrogen bonds shown as blue dashed lines (PDB ID: 1M2Z) [142]. The C3 ketone from the A-ring interacts with Gln570 and Arg611 belonging to H3 (orange) and H5 (yellow), respectively. The C11 hydroxy group from the C-ring interacts with Asn564 belonging to H3 (orange). The C17 hydroxy group from the D-ring interacts with Q642 belonging to H7 (green). The C20 carbonyl and C21 hydroxy group interact with Thr739 belonging to H11 (purple).