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Structural overview of velsecorat and fluticasone furoate (FF) bound in the GR LBP with hydrogen bonds shown as blue dashed lines (PDB ID: 7PRW and 7PRV, respectively) [122]. (a) Both ligands interact with Asn564 and Gln642 to stabilize H12. (b) Velsecorat extends in a novel pocket beneath Trp577, while FF interacts with Arg611 and Gln570.
