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. Author manuscript; available in PMC: 2023 Jun 27.
Published in final edited form as: Acta Biomater. 2022 Jun 2;148:171–180. doi: 10.1016/j.actbio.2022.05.049

Table 2:

Endothelial Cell Parameters

Parameter Name Definition Value Justification
CULTURE_RADIUS Spheroid radius 140 μm Estimated from experiments
SIGHT_RADIUS Distance an EC can sense 20 μm [14]
PERSISTENCY_TIME Minimum time between direction changes 3 hrs [14]
MAX_ELONGATION_LENGTH Required elongation length before a cell can proliferate 40 μm [14]
MIGRATION_RATE Chemotactic migration rate 30 μm/hr [43]
BRANCH_DELAY_TIME Minimum time between branching actions 6 hrs Estimated from [14]
VEGF_SENSITIVITY VEGF threshold necessary for endothelial cells to migrate 0.025 relative units Manual parameter fitting
VESSEL_VEGF_INTAKE Amount of VEGF internalized from the location an endothelial cell occupies 0.001 relative units Manual parameter fitting
INITIAL_PERCENT_HEAD_CELLS Percentage of initial spheroid head cells 7% Estimated from experiments
REQUIRED_VEGF_GRADIENT Required difference between the amount of VEGF at the new location compared to the current location 0.005 relative units Estimated
BRANCHING_PROBABILITY Probability of branching based on GF concentration GF Conc.   Probability
<0.05 relative units  0.4
0.05-0.25 relative units 0.55
>0.25 relative units  0.9
Estimated from [14]