Table 2:
Parameter Name | Definition | Value | Justification |
---|---|---|---|
CULTURE_RADIUS | Spheroid radius | 140 μm | Estimated from experiments |
SIGHT_RADIUS | Distance an EC can sense | 20 μm | [14] |
PERSISTENCY_TIME | Minimum time between direction changes | 3 hrs | [14] |
MAX_ELONGATION_LENGTH | Required elongation length before a cell can proliferate | 40 μm | [14] |
MIGRATION_RATE | Chemotactic migration rate | 30 μm/hr | [43] |
BRANCH_DELAY_TIME | Minimum time between branching actions | 6 hrs | Estimated from [14] |
VEGF_SENSITIVITY | VEGF threshold necessary for endothelial cells to migrate | 0.025 relative units | Manual parameter fitting |
VESSEL_VEGF_INTAKE | Amount of VEGF internalized from the location an endothelial cell occupies | 0.001 relative units | Manual parameter fitting |
INITIAL_PERCENT_HEAD_CELLS | Percentage of initial spheroid head cells | 7% | Estimated from experiments |
REQUIRED_VEGF_GRADIENT | Required difference between the amount of VEGF at the new location compared to the current location | 0.005 relative units | Estimated |
BRANCHING_PROBABILITY | Probability of branching based on GF concentration |
GF Conc. Probability <0.05 relative units 0.4 0.05-0.25 relative units 0.55 >0.25 relative units 0.9 |
Estimated from [14] |