FIG 5.
OVA-induced allergic diarrhea is abrogated in TSLPR-deficient mice. (A) Protocol. (B) Percentage of diarrhea occurrences in OVA + ASP patched mice was compiled from 3 separate experiments. (C) Blood levels of MCPT1 in OVA + ASP patched mice were assessed 1 day after last intragastric OVA challenge. (D and E) CEA-stained jejunum mucosal mast cells were counted in at least 15 HPFs (original magnification 320). Among lin−cKit+IgE+ mast cells, amount of (E) surface IgE and (F) surface LAMP1 was determined by MFI. Blood MCPT1 levels after last intragastric OVA challenge. (G) Spearman correlation matrix among parameters in mice. Dotted-line boxes denote mice with diarrhea. CEA, Chloro-acetate esterase mast cell stain; HPF, high-power field; MFI, mean fluorescent intensity.