Table 1.

Effects of empagliflozin on vascular function in ALDH2*2 mice using wire myograph.

	WT	Vehicle	EtOH	Empa
Maximal Contractile Force (mN/mg)	0.44 ± 0.03	0.35 ± 0.01#	0.29 ± 0.02$	0.45 ± 0.04%*
Maximal Relaxation (%)	91.8 ± 1.4%	81.1 ± 4.0%#	47.0 ± 13.2%$	91.2 ± 1.7%*

Data correspond to results presented in Fig. 7 (E and F). The maximal contractile force was recorded in response to 1 μM endothelin-1 (ET-1), and the relaxation maximal relaxation (%) was recorded in response to 1 mM acetylcholine in mouse aortas isolated from WT, vehicle, EtOH, and Empa groups. WT group, wild-type Aldh2 mice; vehicle group, solvent (PEG/DMSO) control– treated ALDH2*1/*2 mice; EtOH group, alcohol-treated ALDH2*1/*2 mice; Empa group, ethanol- and Empa-treated ALDH2*1/*2 mice. Data represent six mice for each group. Data are expressed as means ± SEM.

Vehicle versus WT group: #P < 0.05

EtOH versus vehicle group: $P < 0.05

EtOH versus Empa group: *P < 0.05, calculated by a one-way ANOVA with Bonferroni correction.