Table 2.
Univariate and multivariate Cox regression analyses.
| Univariate | Multivariate | |||||
|---|---|---|---|---|---|---|
| HR | 95% CI | p-Value | HR | 95% CI | p-Value | |
| CD163/CD8 EF | ||||||
| High ≥ 16.25/HPF | 1.00 | 1.00 | ||||
| Low < 16.25/HPF | 0.23 | 0.09–0.57 | 0.002 | 0.38 | 0.13–1.09 | 0.07 |
| CD56/M4A4A EF | ||||||
| High ≥ 18/HPF | 1.00 | 1.00 | ||||
| Low < 18/HPF | 0.23 | 0.09–0.59 | 0.002 | 0.51 | 0.16–1.60 | 0.25 |
| CD68 IF | ||||||
| High ≥ 32.5/HPF | 1.00 | 1.00 | ||||
| Low < 32.5/HPF | 8.72 | 1.17–64.82 | 0.03 | 6.05 | 0.76–48.3 | 0.09 |
| CD68 EF | ||||||
| High ≥ 39.75/HPF | 1.00 | |||||
| Low < 39.75/HPF | 2.10 | 0.88–4.96 | 0.10 | |||
| PD1 IF | ||||||
| High ≥ 53.75/HPF | 1.00 | 1.00 | ||||
| Low < 53.75/HPF | 2.97 | 1.08–8.20 | 0.04 | 1.52 | 0.44–5.20 | 0.51 |
| PD1 EF | ||||||
| High ≥ 34/HPF | 1.00 | |||||
| Low < 34/HPF | 0.48 | 0.18–1.23 | 0.13 | |||
| Stage | ||||||
| IV | 1.00 | |||||
| III | 0.96 | 0.37–2.46 | 0.93 | |||
| II | 0.28 | 0.06–1.25 | 0.09 | |||
| I | 0.36 | 0.10–1.30 | 0.12 | |||
| Grade | ||||||
| I/II | 1.00 | |||||
| III | 1.37 | 0.60–3.11 | 0.45 | |||
| FLIPI | ||||||
| H/I | 1.00 | |||||
| L | 0.53 | 0.21–1.37 | 0.19 | |||
| BCL2 | ||||||
| p | 1.00 | |||||
| n | 0.24 | 0.06–1.04 | 0.06 | |||
FLIPI, Follicular Lymphoma international prognostic index; HR, hazard ratio; CI, confidence interval; HPF, high-power field; EF, extrafollicular; IF, intrafollicular.