Table 6.

Multiple linear regression analysis for identification influence of independent factors to peak concentration level of dabigatran.

Characteristics	Unstandardized Coefficients		Standardized Coefficients	t	p Value	95% Confidence Interval
	B	Std. Error	β			Lower Bound	Upper Bound
(Constant)	56.0	126.6		0.44	0.66	−194.4	306.5
CES1, rs8192935	23.9	11.9	0.22	2.00	0.05 *	0.26	47.7
ABCB1, rs1128503	−17.9	12.2	−0.19	−1.47	0.14	−42.2	6.27
CES1, rs2244613	−7.98	10.8	−0.08	−0.74	0.46	−29.4	13.4
ABCB1, rs4148738	−1.89	27.7	−0.02	−0.07	0.95	−56.7	52.9
ABCB1, rs1045642	4.69	15.6	0.05	0.30	0.76	−26.2	35.6
ABCB1, rs2032582	−5.17	18.9	−0.06	−0.27	0.79	−42.7	32.4
CES1, rs71647871	15.4	51.7	0.02	0.29	0.77	−86.9	117.7
Age, years	−0.33	0.64	−0.05	−0.51	0.61	−1.58	0.93
BMI, (kg/m)	−3.23	1.71	−0.16	−1.89	0.06	−6.61	0.14
Gender (male, female)	28.8	13.8	0.19	2.09	0.04 *	1.52	56.1
APTT, sec	2.55	0.97	0.25	2.64	0.009 *	0.64	4.47
PT, sec	−2.76	2.23	−0.12	−1.24	0.22	−7.17	1.65
FBG, g/L	−0.14	6.54	−0.002	−0.02	0.98	−13.1	12.8
ALT, U/L	0.77	0.81	0.10	0.95	0.34	−0.83	2.36
AST, U/L	0.06	0.87	0.007	0.07	0.95	−1.67	1.78
CRE, mg/dL	20.4	40.2	0.05	0.51	0.61	−59.2	99.9

Note: Continuous variables are presented, mean ± SD and categorical variables as n (%). The significant p value (p < 0.05); Abbreviations: BMI, body mass index; APTT, activated partial thromboplastin time; PT, prothrombin time; FBG, fibrinogen; ALT, alanine aminotransferase; AST, aspartate aminotransferase; CRE, creatinine.