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. 2023 Jun 7;24(12):9842. doi: 10.3390/ijms24129842

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© 2023 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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Analysis of changes in the contacts of rDNA clusters with genes following induced differentiation in K562 cells. (A) The volcano plot presents statistically significant changes (padj < 0.05) in contacts of genes with rDNA clusters determined in 4C-rDNA experiments. (B) The top 10 detected terms of biological processes associated with genes that increased the number of contacts with rDNA clusters. The search was performed using g:Profiler (https://biit.cs.ut.ee/gprofiler/gost, 4 June 2023). The values to the right of the bars show the number of rDNA-contacting genes associated with a term. The list of corresponding genes is shown in Table S6. (C) The top 10 detected terms of biological processes associated with genes that decreased the number of contacts with rDNA clusters. The values to the right of the bars show the number of rDNA-contacting genes associated with a term. The list of corresponding genes is shown in Table S7.