Table 1.
MSC-therapy-related adverse events described in the clinical trials.
| Reference | Follow-Up (Years) | AE | Number of Patients | Percentage of N | Duration of AE | Intensity of AE |
|---|---|---|---|---|---|---|
| [19] | 1 | Joint pain | 6 | 50% | 1–6 days | Mild |
| Joint inflammation | 3 | 25% | NA | Mild | ||
| Back pain | 3 | 25% | NA | Mild | ||
| Tendonitis | 1 | 8% | NA | Mild | ||
| [20] | 1 | Joint swelling | 2 | 13% | NA | Mild |
| Joint lock | 1 | 6% | NA | Mild | ||
| Back pain | 3 | 20% | 2–3 days | Mild | ||
| Arthralgia | 8 | 53% | 2–3 days | Mild | ||
| [22] | 1–2 | Joint pain | 2 | 15% | 1 day | Mild |
| Joint swelling | 1 | 8% | 2 days | Mild | ||
| [25] | 1 | Joint pain | 4 | 33% | 2–4 weeks | Mild |
| Joint swelling | 2 | 17% | 4 weeks | Mild | ||
| [30] | 0.5 | Joint pain and swelling | 1 | 2% | 2 days | Mild |
| [32] | 0.5 | Joint swelling | 3 | 12% | 6 months | Moderate |
| [33] | 1 | Joint swelling | 2 | 8% | 12 months | Moderate |
| [40] | 0.5 | Joint swelling | 5 | 28% | NA | Mild |
| [41] | 0.5 | Arthralgia | 6 | 50% | 6 months | Moderate |
| Joint swelling | 2 | 17% | 6 months | Moderate | ||
| [42] | 1 | Joint pain and swelling | 2 | 7% | 4 weeks | Mild |
| Discomfort and bruising | 18 | 60% | NA | Mild | ||
| [43] | 0.5–1 | Joint swelling | 1 | 3% | NA | Mild |
| [44] | 2 | Joint pain | 4 | 11% | NA | Mild |
| Joint swelling | 15 | 44% | NA | Mild | ||
| Joint edema and cramps | 1 | 3% | NA | Mild | ||
| [45] | 1 | Joint pain and swelling | 19 | 36% | 7 days | Mild |
| [46] | 2 | Joint pain and swelling | 5 | 17% | NA | Mild |
| Skin erythema | 2 | 7% | NA | Mild | ||
| [28] | 1 | Joint pain and swelling | 8 | 53% | 7 days | Mild |
| [29] | 1 | Joint pain and swelling | 4 | 7% | NA | Mild |
| Arthralgia | 2 | 3% | NA | Mild | ||
| [47] | 1 | Joint pain | 18 | 82% | 3 weeks | Moderate |
| Joint swelling | 3 | 14% | 3 weeks | Mild | ||
| Joint edema | 10 | 45% | 3 weeks | Mild | ||
| [51] | 1 | Joint pain | 9 | 16% | NA | Mild |
| Joint swelling | 6 | 10% | NA | Mild | ||
| Arthralgia | 8 | 14% | NA | Mild | ||
| Joint stiffness | 2 | 3% | NA | Mild | ||
| [54] | 7 | Arthralgia | 2 | 30% | NA | Mild |
| Back pain | 1 | 14% | NA | Mild | ||
| Increased infection susceptibility | 1 | 14% | NA | Mild | ||
| [56] | 0.5 | Joint pain and swelling | 4 | 20% | 3 days | Mild |
| [37] | 1.5 | Joint swelling | 8 | 23% | NA | Mild |
| Arthralgia | 13 | 37% | NA | Mild | ||
| Crepitations | 5 | 14% | NA | Mild |
NA: not available.