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. 2023 Jun 12;24(12):10033. doi: 10.3390/ijms241210033

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© 2023 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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The common and specific core signaling pathways and their downstream cellular dysfunctions between psoriasis and non-psoriasis. The figure shows the core genetic and epigenetic signaling pathways and pathogenic mechanisms of psoriasis. The left block contains the specific core signaling pathways of psoriasis. The middle block contains the overlapping core signaling pathways between psoriasis and non-psoriasis. The right block contains the specific core signaling pathways of non-psoriasis. The gene symbols in red or green font denote the selected significant biomarkers of the pathogenesis of psoriasis as drug targets of psoriasis.