Table 1.

DNA binding motif sequence of STATs and their DNA target.

	DBD Sequence (Protein)	Optimal Binding Sequence (DNA) [131]
STAT1	317-FVVERQPCMPTHPQRPLVLKTGVQFTVKLRLLVKLQELNYNLKVKVLFDKDVNERNTV KGFRKFNILGTHTKVMNMEESTNGSLAAEFRHLQLKEQKNAGTRTNEGPLIVTEELHSL SFETQLCQPGLVIDLETTSLPVVVISNVSQLPSGWASILWYNML-437	TTCCCGTA
STAT2	312-FVVETQPCMPQTPHRPLILKTGSKFTVRTRLLVRLQEGNESLTVEVSIDRNPPQL QGFRKFNILTSNQKTLTPEKGQSQGLIWDFGYLTLVEQRSGGSGKGSNKGPLGV TEELHIISFTVKYTYQGLKQELKTDTLPVVIISNMNQLSIAWASVLWFNLL-432	GGGAAACCGAAACTG
STAT3	321-FVVERQPCMPMHPDRPLVIKTGVQFTTKVRLLVKFPELNYQLKIKVCIDKDSGD VAALRGSRKFNILGTNTKVMNMEESNNGSLSAEFKHLTLREQRCGNGGRANC DASLIVTEELHLITFETEVYHQGLKIDLETHSLPVVVISNICQMPNAWASILWYN MLT-421	TTCCCGTAA
STAT4	316-FVVERQPCMPTHPQRPLVLKTLIQFTVKLRLLIKLPELNYQVKVKASIDKNVSTL SNRRFVLCGTNVKAMSIEESSNGSLSVEFRHLQPKEMKSSAGGKGNEGCHMVT EELHSITFETQICLYGLTIDLETSSLPVVMISNVSQLPNAWASIIWYNVS-436	TTCCCAGAA
STAT5	332-FIIEKQPPQVLKTQTKFAATVRLLVGGKLNVHMNPPQVKATIISEQQAKSLLKN ENTRNECSGEILNNCCVMEYHQATGTLSAHFRNMSLKRIKRADRRGAESVTEE KFTVLFESQFSVGSNELVFQVKTLSLPVVVIVHGSQDHNATATVLWDNAFA-452	TTCCTGGAA
STAT6	273-FLVEKQPPQVLKTQTKFQAGVRFLLGLRFLGAPAKPPLVRADMVTEKQARELS VPQGPGAESTGEIINNTVPLENSIPGNCCSALFKNLLLKKIKRCERKGTESVTEEK CAVLFSASFTLGPGKLPIQLQALSLPLVVIVHGNQDNNAKATILWDNAF-393	TTCTGGAA

All STATs can bind to canonical STAT-binding site TTNNNNNAA.