. 2023 Jun 12;24(12):10021. doi: 10.3390/ijms241210021

Table 1.

Models of neurodegenerative diseases and outcomes after intervention.

Diseases	Biological Model	Intervention Measure	Consequence	Reference
Traumatic Brain Injury	Controlled cortical impact (CCI)	/	ACSL4 expression level increased	[66]
Traumatic Brain Injury	CCI	Baicalein	Decreased ferroptotic PE oxidation	[67]
Ischemic stroke	Middle cerebral artery occlusion (MCAO)	/	ACSL4 increased after decreasing 1–3 h of ischemia	[46]
Ischemic stroke	MCAO	liproxstatin-1/Rosiglitazo-ne/	Lipid peroxidation index was significantly inhibited in comparison with untreated group	[73]
Hemorrhagic stroke	Oxygen and glucose deprivation (OGD)	/	ACSL4 mRNA expression was significantly increased	[46]
Hemorrhagic stroke	OGD	Paeonol	Paeonol inhibited the expression of ACSL4	[50]
Alzheimer’s disease	APPswe transgenic mice	/	Aβ accumulates in brain tissue due to lipid peroxidation	[74]
Alzheimer’s disease	APPswe/PSEN1dE9 (APP/PS1) double transgene mice	tetrahydroxy stilbene glycoside (TSG)	TSG inhibited the expression of ACSL4	[75]
Parkinson’s disease	PD mice model	1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)	The expression of ACSL4 significantly increased	[76]
Parkinson’s disease	PD mice model	β-hydroxybutyrate (BHB)	BHB inhibits ferroptosis in PD model	[77]
Spinal cord injury	Spinal cord	Edaravone	Reduces ACSL4 levels	[54]
Spinal cord injury	contusion injury model	Edaravone	Reduces ACSL4 levels	[54]
Multiple sclerosis	Experimental autoimmune encephalitis (EAE) model	ACSL4-KO	Knocking down the ACSL4 gene considerably reduced the severity of EAE and the clinical score of EAE mice	[78]