Table 1.

Representative DNA methyltransferase inhibitors.

Classification	Drugs	Mechanisms	Status of Clinical Use	Refs.
Cytosine nucleoside derivatives	5-aza RX-3117	Incorporate DNA and participate in DNA replication	clinical application preclinical study	[34,35]
Deoxyribose analogs	5-aza-dc	incorporate DNA and participate in DNA replication	clinical application	[37]
Benzoamide	Zebularine RG108 SGI-1027	bind non-covalently to the active sites of DNMTs	preclinical study preclinical study preclinical study	[38,39,40]
Aminobenzoic acid derivatives	Procainamide Procaine	bind to the CpG sites	Clinical phase II Clinical phase II	[42,43]
Antisense oligonucleotide   Polyphenols	MG-98 miR29a   EGCG curcumin γ-oryzanol	act on DNMT1 mRNA     Bind the active site of DNMT enzyme, bind to DNMT sulfhydryl	Clinical phase II preclinical study   preclinical study preclinical study preclinical study	[44,45,47,48,49]