Table 2.

Representative drugs for AUD.

Drugs	Mechanism	Function	Status of Clinical Use	Refs
ALDH   FANCD2   Glutathione     Folic acid   Vitamin B6/B12	Reduce DNA damage and maintain DNA activity Reduce DNA damage and maintain DNA activity Neutralize free radicals, transport cysteine, and REDOX cells Methyl donor   Methyl donor	Improve hematopoietic function, protect the liver Improve hematopoietic function, protect the liver Promote cell regeneration     Improve oxidative damage and cognitive impairment Improve oxidative damage and cognitive impairment	preclinical study   preclinical study   clinical application     clinical application   clinical application	[122,123,124,125,127,131]
Curcumin   betaine Lucidum     Cordyceps sinensis	Increase methylation levels   provide methyl groups to make S-adenosine Increase the expression of histone H3, DNMT3A and DNMT3B. Promote DNA methylation reprogramming	Resist cell oxidative damage and apoptosis Repairing damage to embryonic development Improve oxidative damage and cognitive impairment   Improve brain atrophy and learning and memory function	clinical application   clinical application   clinical application     clinical application	[132,133,134,135,136]