Figure 1.

Western-diet-fed ovariectomized mice displayed increased body fat, basal glucose, plasma insulin, and glucose intolerance. Initial body weight (before surgery and diet) and final body weight (after 7 weeks of WD) of SHAM mice, SHAM mice fed with Western diet (WD) (SHAM + WD) for 7 weeks, OVX mice, and OVX mice fed with Western diet (WD) for 7 weeks (OVX + WD) (A). Initial body fat (before surgery and diet) and final body fat (after 7 weeks of WD) (B). Basal glucose (C). Plasma insulin (D). Plasma glucose (E). Area under curve (AUC) of plasma glucose in different times (F). Data are represented as mean ± SEM. The statistical differences as indicated by two-way ANOVA.