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. 2023 Jun 8;24(12):9896. doi: 10.3390/ijms24129896

Figure 3.

Figure 3

Irisin prevents subchondral bone loss in the tibiae of Ovx mice. (a) Representative micro-CT-generated section images and calculated parameters of subchondral bone in the tibiae harvested from Sham-veh mice, Ovx-veh mice and Ovx-irisin mice. (b–e) Trabecular bone parameters included bone volume/total volume (BV/TV), trabecular number (Tb.N), trabecular thickness (Tb.Th) and trabecular separation (Tb Sp) in Sham-veh (n = 5), Ovx-veh (n = 5) and Ovx-irisin (n = 5) mice. Kruskal–Wallis with Dunn’s multiple comparison tests was performed. Data are presented as box-and-whisker plots with median and interquartile ranges, from max to min, with all data points shown. * p < 0.05, ** p < 0.01 vs. Sham-veh.