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. 2023 Jun 8;24(12):9896. doi: 10.3390/ijms24129896

Figure 5.

Figure 5

Irisin treatment inhibits bone loss in the spines of Ovx mice. (a) Von Kossa-stained vertebral sections and trabecular bone parameters from Sham-veh mice, Ovx-veh mice and Ovx-irisin mice (magnification 2×). (b–e) Trabecular bone parameters included bone volume/total volume (BV/TV) in Sham-veh (n = 7), Ovx-veh (n = 9) and Ovx-irisin (n = 7) mice; trabecular number (Tb.N) in Sham-veh (n = 7), Ovx-veh (n = 9) and Ovx-irisin (n = 7) mice; trabecular thickness (Tb.Th) in Sham-veh (n = 7), Ovx-veh (n = 9) and Ovx-irisin (n = 7) mice; and trabecular separation (Tb Sp) in Sham-veh (n = 7), Ovx-veh (n = 9) and Ovx-irisin (n = 7) mice. A one-way ANOVA with Tukey’s multiple comparisons tests was performed in (b–d). Kruskal–Wallis with Dunn’s multiple comparison tests was performed in (e). Data are presented as box-and-whisker plots with median and interquartile ranges, from max to min, with all data points shown. ** p < 0.01 vs. Sham-veh, # p < 0.05 vs. Ovx-veh.