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(A) Genotype distribution at embryonic day 9 (E9), the day of birth (P0) and at genotyping age (P10 to P21). Number of animals analyzed along with the P value determined by Chi Square analysis is listed at the top. (B) Images of control and mutant mice at embryonic day 9. Note the malformed heart with pericardial effusion (arrow) and the abnormal head closure (arrowhead). Scale bar is 200 microns.
