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(a) Abundance of tau-positive cells in 0.014 mm3 of the cortex and 0.011 mm3 of the brainstem of P301S mice treated with pioglitazone (P301S Pio) or placebo (P301S Placebo) as counted from triplicates of immunohistological stainings with AT8. (b) Representative orthogonal projections of AT8 immunohistochemistry for the cortex (left panel) and the brainstem (right panel) of two P301S mice treated with pioglitazone and placebo, respectively.
