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(a,b) Microglial activation (area%) in the cortex and the brainstem of P301S mice at 8.2 months of age treated with pioglitazone (P301S Pio) or placebo (P301S Placebo) as quantified by analyzing triplicates of immunohistochemical stainings with Iba1 (a) and CD68 (b). (c,d) Representative orthogonal projections of immunohistochemical stainings of P301S mice treated with pioglitazone (P301S Pio) or placebo (P301S Placebo) in the cortex (c) and the brainstem (d).
