Table 1.
Comparison of international guidelines’ definitions/diagnostic criteria for recurrent pregnancy loss.
| Criteria | Guidelines (Year of Publication) | ||||
|---|---|---|---|---|---|
| WHO (1977) |
RCOG (2011) |
ASRM (2012/2013) |
ESHRE (2017/2022) |
DGGG/ÖGGG/SGGG (2018) | |
| Number of RPLs (n) | 3 | 3 | 2 | 2 | 3 |
| Sequence of loss | Not specified | Consecutive | Consecutive | Consecutive and non-consecutive | Consecutive and non-consecutive |
| Type of pregnancy | All pregnancy losses, types are not specified | All pregnancy losses, types are not specified | Clinical pregnancies | Non-visualized pregnancy losses (biochemical pregnancy losses and/or resolved and treated pregnancies of unknown location), clinical pregnancies |
All pregnancy losses, types are not specified |
| Evidence of loss | Not specified | Not specified | US or histopathologic examination |
Serum or urine β–hCG; US |
Not specified |
| Gestational age at pregnancy loss (weeks) | 20 (22) | 24 | The first trimester of pregnancy, gestational weeks not specified |
24 | 24 |
| Fetal weight (grams) | <500 | Not specified | Not specified | Not specified | <500 |
ASRM—American Society of Reproductive Medicine; DGGG/ÖGGG/SGGG—German Society of Gynecology and Obstetrics/Austrian Society of Gynecology and Obstetrics/Swiss Society of Gynecology and Obstetrics; ESHRE—European Society of Human Reproduction and Embryology; RCOG—Royal College of Obstetricians and Gynecologists; RPL—recurrent pregnancy loss; US—ultrasonography; WHO—World Health Organization; β-hCG—β human chorionic gonadotropin.