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. 2023 Jun 20;24(12):10384. doi: 10.3390/ijms241210384

Figure 5.

Figure 5

Bulk-RNA sequencing of glomerular monocultures and co-cultures in 2D and 3D exhibits differences in genes involved in hypoxia and housekeeping genes: (a) heatmap demonstrating expression of genes involved in hypoxia response in 2D and 3D monoculture of glomerular endothelial cells (GEC) and mesangial cells (MC) as well as 2D and 3D co-cultures of GEC, MC and differentiated, conditionally immortalized human podocytes (PEM); and (b) heatmap representing alterations of typically used housekeeping genes in 2D compared to 3D monoculture of GEC and MC as well as 2D and 3D glomerular co-cultures.