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. 2023 Jun 15;24(12):10189. doi: 10.3390/ijms241210189

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© 2023 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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(a) Representative original recordings of stimulated systolic Ca²⁺ transients (epifluorescence microscopy, Fura 2-AM, 1 Hz) of human atrial SCN10A or control iPSC-CMs and after additional Na_V1.8 inhibition by PF-01247324. Mean values ± SEM of (b) systolic Ca²⁺ transient amplitude, (c) time to peak 80%, (d) diastolic Ca²⁺ level, and (e) relaxation time 80% in control CMs (n = 48 cells/5 differentiations), SCN10A KO CMs (n = 60/7), and each after treatment with PF-01247324 (control + PF-01247324 n = 30/5, KO + PF-01247324 n = 52/6). Values are presented as mean ± SEM. Mean values per differentiation were compared using one-way ANOVA with Sidak’s test for multiple comparisons to calculate p values.