Table 7.
Comparison of results obtained by qPCR and by dPCR to investigate ABL1 mutations.
T315I | |||||
---|---|---|---|---|---|
Patient ID | Sample ID | qPCR | dPCR | %BCR::ABL1 (IS) | Treatment |
Patient 1 | Sample 1 | WT | WT | 0.054 | Nilotinib |
Sample 2 | T315I | T315I | 100 | ||
Patient 2 | Sample 1 | WT | WT | 22.92 | BMT |
Sample 2 | WT | T315I | NA | ||
Patient 3 | Sample 1 | WT | T315I | 0.281 | BMT |
Patient 4 | Sample 1 | WT | T315I | 0.315 | Dasatinib |
Patient 5 | Sample 1 | WT | T315I | 8.9 | Dasatinib |
Patient 6 | Sample 1 | WT | T315I | 1,38 | Imatinib |
E255K | |||||
Patient ID | Sample ID | qPCR | dPCR | %BCR::ABL1 (IS) | Treatment |
Patient 7 | Sample 1 | WT | WT | 61.12 | Imatinib |
Sample 2 | WT | E255K | 72.7 | ||
Sample 3 | E255K | E255K | 80.6 | ||
Sample 4 | WT | WT | 8.19 | Dasatinib | |
V359F | |||||
Patient ID | Sample ID | qPCR | dPCR | %BCR::ABL1 (IS) | treatment |
Patient 8 | Sample 1 | WT | WT | 47.3 | None |
Sample 2 | V359F | V359F | 43.2 | Nilotinib |
Wt represents “wild-type”; BMT “Bone marrow transplantation”; and NA “Not available”.