TABLE 1.
lncRNAs involved in regulating tumor metabolism.
| lncRNA | Target | Action | Tumor type | Ref. |
|---|---|---|---|---|
| Glucose metabolism | ||||
| TUG1 | miR-455-3P | Up | Hepatocellular carcinoma | Lin et al. (2018b) |
| PVT1 | miR-143 | Up | Gallbladder cancer | Chen et al. (2019) |
| lncRNA FEZF1-AS1 | PKM2 | Up | Colorectal cancer | Nagarajan et al. (2017) |
| lnc-p23154 | miR-378a-3p | Up | Oral squamous cell carcinoma | Wang et al. (2018a) |
| SAMMSON | P32 | Interact | Melanoma | Leucci et al. (2016) |
| MALAT1 | TCF7L2 | Up | Hepatocellular carcinoma | Malakar et al. (2019) |
| lncRNA MACC1-AS1 | AMPK/Lin28 | Up | Gastric cancer | Zhao et al. (2018) |
| lncRNA MACC1-AS1 | PAX8 | Up | Pancreatic cancer | Qi et al. (2019) |
| LINC00092 | PFKFB2 | Up | Ovarian cancer | Zhao et al. (2017) |
| LINC00963 | PGK1 | Up | Non–small-cell lung tumor | Yu et al. (2017) |
| Lipid metabolism | ||||
| HULC | miR-9 | Up | Hepatocellular carcinoma | Cui et al. (2015) |
| Glutamine metabolism | ||||
| GLS-AS | GLS | Down | Pancreatic cancer | Deng et al. (2019) |
| OIP5-AS1 | miR-217 | Up | Melanoma | Luan et al. (2019) |
| UCA1 | miR-16 | Up | Bladder cancer | Li et al. (2015a) |
Up/down indicates lncRNA upregulating or downregulating the expression of target genes. PKM2, pyruvate kinase isozymes M2; GLS, glutaminase; PFKFB, 2,6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; TCF7L2, transcription factor 7-like 2; LDH, lactate dehydrogenase.