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Connectivity analysis data. Connectivity studies have documented changes in functional connectivity in the placebo analgesic effect between PreCUN-HPC, MTG–PoCG, and rACC–PAG–RVM). In the nocebo hyperalgesic effect, functional connectivity changes have been observed among HPC/Operculum and many brain areas, namely ACC, INS, M1, and S1. In addition, functional connectivity between HPC and PAG and Amg has been suggested to play a role in the nocebo hyperalgesic effect.
