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COX5A attenuates DOX-induced oxidative stress and apoptosis in mice. (A) Representative DHE staining images. Oxidized DHE intercalates into DNA and the nuclei appear in red. Scale bar = 100 μm. (B) Quantitative analysis of DHE-positive nuclei. (C) Representative IHC staining images of 4-HNE. (D–I) Western blot analysis of the protein level of COX5A, SOD2, Bax/Bcl-2, cleaved caspase-3/caspase-3, and p-Akt(S473)/t-Akt. Data are expressed as mean ± SEM. * p < 0.05.
