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. 2023 Jun 19;14(6):326. doi: 10.3390/jfb14060326

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© 2023 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

PMC Copyright notice

(A) A proposed model for how Mg-ion-mediated TRPM7/PI3K pathway signals confer osteogenesis and resistance to alkaline-stress-induced cytotoxicity in human osteoblasts © [127]. (B) Mechanism of the stimulatory effects of Mg²⁺ on the efficacy of BMP-2 © [128]. Note: TRPM7: transient receptor potential melastatin 7; PI3K: phosphoinositide 3-kinase; BMP-2: bone morphogenetic protein-2.