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In vitro effects of compounds 1, 2, 3, 5, 6, and 8 on the release of inflammatory mediators in macrophages.
| Compound | IC50 (µM) | |||
|---|---|---|---|---|
| PGE2 | IL-6 | CCL2 | NO | |
| 1 | ND | ND | 8 | ND |
| 2 | 1.91 | 1.23 | 1.52 | 2.42 |
| 3 | 1.48 | 5.21 | 1.5 | 5.23 |
| 5 | 1.92 | ND | ND | ND |
| 6 | 1.12 | ND | ND | ND |
| 8 | 20.52 | 9.04 | 19.27 | ND |
