TABLE 1.
The summary of the collaborative studies conducted in the Russian Medical Academy of Continuous Professional Education. This features the collaborations between Clinical Departments and the Pharmacogenomics Center.
| Department | Condition/Drug | Article |
|---|---|---|
| Department of Clinical Pharmacology and Therapy | Hypertension/Losartan | Sinitsina II, Boyarko AV, Temirbulatov II, et al.CYP2C9 gene polymorphisms influence on antihypertensive effectiveness and hypouricemic effect of losartan among patients with arterial hypertension: an observational study [published online ahead of print, 2022 December 29]. Drug Metab Pers Ther. 2022;10.1515/dmpt-2022-0115. doi:10.1515/dmpt-2022-0115 |
| Department of Urgent and General Surgery | Post-op Pain Management/Ketorolac, Tramadol | Muradian AA, Sychev DA, Blagovestnov DA, et al. The effect ofCYP2D6 and CYP2C9 gene polymorphisms on the efficacy and safety of the combination of tramadol and ketorolac used for postoperative pain management in patients after video laparoscopic cholecystectomy. Drug Metab Pers Ther. 2021;371):27-34. Published 2021 July 12. doi:10.1515/dmpt-2021-0112 |
| Ophthalmology Department | Glaucoma/Timolol | Moshetova LK, Soshina MM, Turkina KI, et al. Effect ofCYP2D6*4, CYP2D6*10 polymorphisms on the safety of treatment with timolol maleate in patients with glaucoma [published online ahead of print, 2022 August 24]. Drug Metab Pers Ther. 2022;10.1515/dmpt-2022-0117. doi:10.1515/dmpt-2022-0117 |
| Interventional Cardiology Department | Atrial Fibrillation/Rivaroxaban | Rytkin E, Bure IV, Bochkov PO, et al. MicroRNAs as novel biomarkers for rivaroxaban therapeutic drug monitoring.Drug Metab Pers Ther. 2021;371):41-46. Published 2021 August 13. doi:10.1515/dmpt-2021-0118 |
| Department of Radiotherapy and Radiology | Thyroid Cancer/Radioiodine | Denisenko NP, Shuev GN, Mukhamadiev RH, et al. Genetic markers associated with resistance to radioiodine therapy in thyroid cancer patients: Prospective cohort study. J Mod Oncol. 2022;243):345-350. doi: 10.26442/18151434.2022.3.201867 |
| Department of Clinical Pharmacology and Therapy | Hypertension/Enalapril | Sychev IV, Denisenko NP, Kachanova AA, et al. Pharmacogenetic predictors of development of secondary to enalapril dry cough in hypertensive patients [published online ahead of print, 2023 May 19]. Drug Metab Pers Ther. 2023;10.1515/dmpt-2023-0008. doi:10.1515/dmpt-2023-0008 |
| Department of Infectious Diseases | COVID-19/Remdesivir | Temirbulatov II, Kryukov AV, Mirzaev KB, et al. The Effect of Carriage of CYP3A53 and CYP3A422 Polymorphic Variants on the Safety of Remdesivir Therapy in Patients with COVID-19. Antibiot Khimioter. 2022;67 (45145):45-50. PMID: covidwho-2245708 |
| Interventional Cardiology Department | Acute Coronary Syndrome/Clopidogrel, Ticagrelor | Rytkin E, Mirzaev K, Bure I, et al. MicroRNAs as Novel Biomarkers for P2Y12 - Inhibitors Resistance Prediction.Pharmgenomics Pers Med. 2021;14:1575-1582. Published 2021 December 2. doi:10.2147/PGPM.S324612 |
| Interventional Cardiology Department | Atrial Fibrillation/Calcium Channel Blockers | Sychev D, Mirzaev K, Cherniaeva M, et al. Drug-drug interaction of rivaroxaban and calcium channel blockers in patients aged 80 years and older with nonvalvular atrial fibrillation.Drug Metab Pers Ther. 2020;353):10.1515/dmpt-2020-0127. Published 2020 September 4. doi:10.1515/dmpt-2020-0127 |
| Psychiatry Department | Psychotic Disorder/Haloperidol | Parkhomenko AA, Zastrozhin MS, Pozdnyakov SA, et al. Association of CYP2D6*4 Polymorphism with the Steady-State Concentration of Haloperidol in Patients with Alcohol-Induced Psychotic Disorders.Psychopharmacol Bull. 2022;524):52-60 |