Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2023 Jun 13;11:1169962. doi: 10.3389/fcell.2023.1169962

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

Copyright © 2023 Hipke, Pitter, Hruscha, van Bebber, Modic, Bansal, Lewandowski, Orozco, Edbauer, Bonn, Haass, Pohl, Montanez and Schmid.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

PMC Copyright notice

The tardbp−/−; tardbpl−/− mutant vascular phenotype is cell autonomous. (A) Scheme of the transplantation of control Tg (fli1:EGFP)^y1 or TDP-43 KO; Tg (fli1:EGFP)^y1 donor EC cells (EC in green, injected tracer label in blue) into Tg (kdrl:HsHRAS-mCherry)^s896 hosts (EC in red). (B) The region of interest (ROI) imaged in the transplanted donor larvae is the area dorsal to the end of the yolk sack extension for all images (box). (C) Tg (fli1:EGFP)^y1 donor (EC in green, injected tracer label in blue) transplanted into Tg (kdrl:HsHRAS-mCherry)^s896 recipients (EC in red) had a wild type morphology. TDP-43 KO; Tg (fli1:EGFP)^y1 mutant donor into Tg (kdrl:HsHRAS-mCherry)^s896 recipient showed the TDP-43 deficient phenotype (n = 4). Scale bar 50 μm, anterior to the left. Displayed is the area dorsal to the end of the yolk sack extension for all images.