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. 2023 May 25;19(7):887–899. doi: 10.1038/s41589-023-01344-z

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© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Extended Data Fig. 9 — (a) Histograms of seeded and invaded cells. Ratios of bin heights were used to estimate the local cellular fitness landscape for each Dox concentration. (b) Local cellular fitness landscapes estimated for each Dox concentration. (c) Global consensus cellular fitness landscapes for low-noise and high-noise cells, estimated as weighted averages of local fitness landscapes. (d) Simulated values of high-noise mNF invasiveness (cyan) compared to the experimental invasion landscape (blue - data, dashed blue line – consensus cellular invasion landscape). (e) Representative simulated Ornstein-Uhlenbeck (O-U) time courses of BACH1 levels in 5 single seeded cells. Some time courses terminate when seeded cells with higher BACH1 levels invade. (f) Simulated time courses of cell count above and below the membrane over 50 hours in invasion assays. (g) The shift of means for invading versus control seeded cells according to simulation and experiment, versus theory developed for linear and quadratic approximations of the fitness landscape, for low-noise mNF cells. (h) The shift of CVs for invading versus control seeded cells according to simulation, and experiment versus theory developed for linear and quadratic approximations of the fitness landscape, for low-noise mNF cells. Expt., experimental; Inf., inferred; Sim., simulated.