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. 2023 May 25;19(7):887–899. doi: 10.1038/s41589-023-01344-z

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© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 4 — a, Flow cytometry expression profile changes of invading low-noise BACH1 cells versus seeded cells at multiple points of the invasion landscape (n = 3). b, MFI (top) and CV (bottom) comparison between invading cells and seeded cells (unpaired two-tailed t-test, n = 3, **P < 0.01, ****P < 0.0001). c, Flow cytometry expression profile comparisons for invading low-noise mNF-GFP cells versus seeded cells at three key dox levels. d, MFI (left) and CV (right) of invading versus seeded cells (unpaired two-tailed t-test, n = 3, P > 0.05). e, Cellular invasion landscape (dashed blue line) of low-noise mNF-BACH1 (BL) clone versus log₁₀(mean BACH1 expression) inferred from flow cytometry histograms of seeded and invading cells. Stochastic simulation results (cyan) for cells invading according to their BACH1 level dependent position on the landscape are compared to the experimental data (blue). f, Computationally predicted log₁₀(BACH1 expression) profile changes in the invaded cell population at distinct landscape ranges due to directional (fitness slope uphill and downhill) and divergent (fitness valley) selection. Expt., experimental; Inf., inferred; Sim., simulated.

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