Implementing a multifaceted intervention that employs the Drug Burden Index as a risk assessment tool, when coupled with a stewardship program, may help hospital clinicians deprescribe inappropriate medications with sedative and/or anticholinergic effects.

Amongst sedative and anticholinergic medications, opioids were the most likely to be deprescribed as a result of the proposed approach.

Further studies are needed to establish more robust evidence regarding the generalisability of this care model across different populations and its effectiveness in deprescribing inappropriate medications in hospitals, with the goal of improving prescribing and clinical outcomes in older adults.