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. 2023 Jun 28;14(6):380. doi: 10.1038/s41419-023-05897-8

Fig. 7. Gal3 inhibition alleviated retinal angiogenesis.

Fig. 7

A CX3CR1-GFP mice were subjected to intravitreous injection of PBS, and anti-Gal3 with 25 and 100 ng/μl on P12 when the OIR model was constructed. B IF staining of retinal vessels (CD31, red) and microglia (CX3CR1, GFP) on P17 in the flat-mounted and cross-section from the blank, PBS, and anti-Gal3(25 and 100 ng/μl) group. (n = 3 per group). Scale bar, 200 µm. C Schematic illustration of the mechanism by which microglia-derived Gal3 promoted retinal angiogenesis. Bars = means ± SD; *P < 0.05; **P < 0.01, NS no significance.