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. 2023 Jun 27;80(7):191. doi: 10.1007/s00018-023-04838-0

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© The Author(s) 2023

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Fig. 3 — The GCT over-represented eccEnhancers may contribute to development of GC. A The top specific eccEnhancers found in GCT. B The 4Dgenome information of the top GCT over-represented enhancers in the FANTOM5 database. C Expression level of the enhancer-interacted target genes in the GC cohort presented in the TCGA database. D Overall survival analysis of the three enh36425’s target genes (ERRFI1, SLC45A1 and PARK7) in GC cohort. E Outward and inward PCR of the eccEnhancer36426s found in 6 different patients. F Sanger sequencing results of the outward and inward-PCR products confirmed the existence of eccDNA junction sites and internal enhancer regions