Table 1.
Clinical characteristics of the patients of the TCGA-COAD-READ cohort. CRC, colorectal cancer; AJCC, American Joint Committee on Cancer; CMS, consensus molecular subtypes; IQR, inter-quartile range. Categorical data reported as n (%). Continuous data reported as median (IQR)
|
Mucinous CRC (n = 72) |
Non-mucinous CRC (n = 522) |
p-value | ||
|---|---|---|---|---|
| Age | 67 (52–77.5) | 68 (58–76) | 0.611 | |
| Sex | Male | 37 (51.4%) | 241 (46.2%) | 0.48 |
| Female | 35 (48.6%) | 281 (53.8%) | ||
| Tumor location (n = 579)a | Colon | 58 (81.7%) | 366 (72%) | 0.115 |
| Rectum | 13 (18.3%) | 142 (28%) | ||
| Stage (n = 574)a | AJCC 1 | 10 (14.1%) | 90 (17.9%) | 0.571 |
| AJCC 2 | 28 (39.4%) | 189 (37.6%) | ||
| AJCC 3 | 25 (35.2%) | 147 (29.2) | ||
| AJCC 4 | 8 (11.3%) | 77 (15.3%) | ||
| T Stage (n = 593)a | T1 | 2 (2.8%) | 18 (3.5%) | 0.528 |
| T2 | 9 (12.5%) | 90 (17.3%) | ||
| T3 | 50 (69.4%) | 358 (68.7%) | ||
| T4 | 11 (15.3%) | 55 (10.6%) | ||
| N Stage (n = 591)a | N0 | 39 (54.2%) | 297 (57.2%) | 0.528 |
| N1 | 16 (22.2%) | 128 (24.7%) | ||
| N2 | 17 (23.6%) | 94 (18.1%) | ||
| M Stage (n = 525)a | M0 | 51 (86.4%) | 389 (83.5%) | 0.693 |
| M1 | 8 (13.6%) | 77 (16.5%) | ||
| Resection margin (n = 438)a | R0 | 51 (96.2%) | 381 (99%) | 0.157 |
| R1/R2 | 2 (3.8%) | 4 (1%) | ||
| Lymphovascular invasion (n = 535)a | Yes | 22 (33.8%) | 197 (41.9%) | 0.269 |
| No | 43 (66.2%) | 273 (58.1%) | ||
| Perineural invasion (n = 230)a | Yes | 6 (22.2%) | 54 (26.6%) | 0.800 |
| No | 21 (77.8%) | 149 (73.4%) | ||
| Vascular invasion (n = 514)a | Yes | 12 (20%) | 115 (25.3%) | 0.459 |
| No | 48 (80%) | 339 (74.7%) | ||
| Microsatellite status (n = 553)a | MSI | 21 (31.8%) | 68 (14%) | < 0.001 |
| MSS | 45 (68.2%) | 419 (86%) | ||
| CMS (n = 536)a | CMS1 | 19 (26.4%) | 61 (11.7%) | < 0.001 |
| CMS2 | 4 (5.6%) | 234 (44.8%) | ||
| CMS3 | 20 (27.8%) | 55 (10.5%) | ||
| CMS4 | 23 (31.9%) | 120 (23%) |
aData not available in full cohort: n in parentheses = number with data available