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. 2023 Jun 14;14:1102433. doi: 10.3389/fphar.2023.1102433

TABLE 1.

Modified from Bucks et al. (Bucks et al., 1988) Percent disposition of topically applied 14C-labeled steroids after a single dose under occluded conditions. HTC = Hilltop chamber. ND = not determined.

Steroid Absorbed 1st HTC 1st Wash 2nd HTC 2nd Wash Total
Hydrocortisone 4.0 ± 2.4 28 ± 5.6 36 ± 3.0 ND ND 68 ± 3.9
Estradiol 27 ± 6.4 41 ± 10 18 ± 7.2 0.5 ± 0.3 ND 87 ± 13
Testosterone 46 ± 15 41​​ ± 8.4 3.0 ± 4.1 0.3 ± 0.2 ND 90 ± 8.4
Progesterone 33 ± 8.9 46 ± 10 1.2 ± 0.8 0.07 ± 0.02 0.01 ± 0.0 80 ± 5.5