TABLE 2.

Modified from Bucks et al. (Bucks et al., 1988) Percent disposition of topically applied 14C-labeled steroids after a single dose under protected (“non-occlusive”) conditions. HTC = Hilltop chamber. ND = not determined. SC “strips” included 14C-radiolabel found in 10 tape strippings of stratum corneum removed after final wash.

Steroid	Absorbed	1st HTC	1st Wash	2nd HTC	2nd Wash	SC “strips”	Total
Hydrocortisone	4.4 ± 1.7	27 ± 11	51 ± 18	3.2 ± 1.7	2.7 ± 1.3	2.5 ± 1.1	89 ± 5.6
Estradiol	3.4 ± 1.2	38 ± 13	58 ± 12	0.7 ± 0.4	0.3 ± 0.4	0.1 ± 0.1	100 ± 0.9
Testosterone	18 ± 8.6	46​​ ± 7.5	30 ± 15	1.4 ± 0.4	0.1 ± 0.08	ND	96 ± 2.0
Progesterone	13 ± 6.3	54 ± 7.7	27 ± 8.7	1.2 ± 0.6	0.3 ± 0.4	ND	96 ± 3.4