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. 2023 Jun 15;61:102041. doi: 10.1016/j.eclinm.2023.102041

Table 1.

Clinical and demographic characteristics of participants.

Training cohort (SeekIn)
Independent validation cohort 1 (SYSMH)
Independent validation cohort 2 (JHUSM)
Cancer
Non-cancer
Cancer
Non-cancer
Cancer
Non-cancer
(n = 591) (n = 1055) (n = 363) (n = 5556) (n = 1005) (n = 812)
Platform Roche cobas e411 Roche cobas e601 Bio-Rad Bioplex 200 platform
Sample type Plasma Serum Plasma
Age
 Mean(SD) 55.3 (13.6) 47.8 (12.4) 58.5 (16.2) 53.8 (17.4) 62.9 (12.4) 49.3 (19.5)
 ≤55 years, n (%) 289 (48.9%) 788 (74.7%) 143 (39.4%) 2840 (51.1%) 279 (22.8%) 408 (50.2%)
 >55 years, n (%) 302 (51.1%) 267 (25.3%) 220 (60.6%) 2716 (48.9%) 726 (72.2%) 404 (49.8%)
Sex
 Female, n (%) 256 (43.3%) 543 (51.5%) 140 (38.6%) 2495 (44.9%) 543 (54.0%) 378 (46.6%)
 Male, n (%) 335 (56.7%) 512 (48.5%) 223 (61.4%) 3061 (55.1%) 462 (46.0%) 434 (53.4%)
Cancer type
 Lymphoma, n (%) 159 (26.9%) 0 (0.0%) 0 (0.0%)
 Liver, n (%) 128 (21.7%) 72 (19.8%) 44 (4.4%)
 Breast, n (%) 66 (11.2%) 16 (4.4%) 209 (20.8%)
 Colorectum, n (%) 62 (10.5%) 46 (12.7%) 388 (38.6%)
 Stomach, n (%) 56 (9.5%) 25 (6.9%) 68 (6.8%)
 Lung, n (%) 41 (6.9%) 155 (42.7%) 104 (10.3%)
 Pancreas, n (%) 17 (2.9%) 15 (4.1%) 93 (9.3%)
 Oesophagus, n (%) 10 (1.7%) 11 (3.0%) 45 (4.5%)
 Ovary, n (%) 5 (0.8%) 23 (6.3%) 54 (5.4%)
 Others, n (%) 47 (8.0%) 0 (0.0%) 0 (0.0%)

SYSMH, Sun Yat-sen Memorial Hospital, Sun Yat-sen University. JHUSM, Johns Hopkins University School of Medicine.