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. 2023 Jun 14;5:1162749. doi: 10.3389/ftox.2023.1162749

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Copyright © 2023 Mozhui, O’Callaghan, Ashbrook, Prins, Zhao, Lu and Jones.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Epigenome-wide association study (EWAS) of CORT+DFP. (A) p-value histograms from the EWAS show a higher frequency of low p-values particularly for the treatment-by-strain interaction effect. This indicates a deviation from the null hypothesis (i.e., a true effect of treatment, but a study that may be underpowered). (B) Mirrored Manhattan plots for treatment-by-strain interaction (top), and treatment effect (bottom). The x-axis plots the location of each CpG region (from chromosomes 1 to X), and the y-axis shows the −Log10P. The red horizontal line marks the nominal significance threshold of −Log10P = 4. Locations of few genes of interest are highlighted.