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. 2023 Jun 14;5:1162749. doi: 10.3389/ftox.2023.1162749

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Copyright © 2023 Mozhui, O’Callaghan, Ashbrook, Prins, Zhao, Lu and Jones.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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A model for the differential response to toxicant exposure based on the methylation pattern for Akr1c14. The C57BL/6J (B6) mice show a loss in methylation following DFP+CORT treatment while the DBA/2J strain remains mostly unchanged. The associated decrease in the expression if Akr1c14 may result in a sustained and greater sensitivity in B6 compared to D2.